Journal Articles

2011

Saeed M, Villarroel M, Reisner AT, Clifford G, Lehman, Moody G, Heldt T, Kyaw TH, Moody B, Mark RG. MIMIC-II: A public-access ICU database. Critical Care Medicine, 2011. In press.

2010

Campana LM, Owens RL, Clifford GD, Pittman SD, Malhotra A. Phase rectiﬁed signal averaging as a sensitive index of autonomic changes with aging. J Appl Physiol, Mar. 2010. [E-print ahead of publication].
Clifford GD, Nemati S, Sameni R. An artiﬁcial vector model for generating abnormal electrocardiographic rhythms. Physiol Meas, 31(5), May 2010. (doi:10.1088/0967-3334/31/5/001)
Heldt T, Mukkamala R, Moody GB, Mark RG. CVSim: an open-source cardiovascular simulator for teaching and research. The Open Pacing, Electrophysiology, and Therapy Journal, 3:45–54, 2010. (doi:10.2174/1876536X01003010045)
Heldt T, Verghese GC. Model-based data integration for clinical environments. Proc. 32nd Annual Conference of IEEE Engineering in Medicine and Biology Society.
Lee J, Mark RG. An investigation of patterns in hemodynamic data indicative of impending hypotension in intensive care. BioMedical Engineering OnLine, 9(62), 2010. (doi:10.1186/1475-925X-9-62)
Monasterio V, Clifford GD, Laguna P, Martinez JP. A multilead scheme based on periodic component analysis for T wave alternans analysis in the ECG. Ann Biomed Eng, 38(8):2532–2541, Aug. 2010. Accepted for publication. (doi:10.1007/s10439-010-0029-z)
Nemati S, Abdala O, Bazan V, Tim-Yeh S, Malhotra A, Clifford GD. A non-parametric surrogate-based test of signiﬁcance for T-wave alternans detection. IEEE Transactions On Biomedical Engineering, 57(2), 2010. In press.
Nemati S, Malhotra A, Clifford GD. Data fusion for improved respiration rate estimation. EURASIP Journal on Advances in Signal Processing, 2010(926305):1–10, May 2010. (doi:10.1155/2010/926305)
Sayadi O, Shamsollahi MB, Clifford GD. Robust detection of premature ventricular contractions using a wave-based bayesian framework. IEEE Transactions on Biomedical Engineering, 57(2):353–362, Feb. 2010. (doi:10.1109/TBME.2009.2031243)

2009

Hug C, Szolovits P. ICU acuity: real-time models versus daily models. AMIA Annu Symp Proc (2009). 260–4. PMCID: PMC2815497
Li, Q., Mark, R.G. and Clifford, G.D. Artificial arterial blood pressure artifact models and an evaluation of a robust blood pressure and heart rate estimator BioMedical Engineering OnLine 2009, 8:13 (8 July 2009). doi:10.1186/1475-925X-8-13.
Clifford, G.D., Long, W.J., Moody, G.B., Szolovits, P., Robust parameter extraction for decision support using multimodal intensive care data, Proc. Royal Soc. Phil. Trans. A, January 28, 2009, Vol. 367, No. 1887, pp 411-429 / doi:10.1098/rsta.2008.0157
Sun JX, Reisner AT, Saeed M, Heldt T, Mark RG.The cardiac output from blood pressure algorithms trial Crit Care Med 2009; 37(1):337-8.
Zhang Y, Hemond MS. Uncovering the predictive value of minimum blood glucose through statistical analysis of a large clinical dataset. AMIA Annu Symp Proc. 2009. Nov. 2009:725–9. PMCID: PMC2815380

2008

Zhang, Ying, Predicting occurrences of acute hypoglycemia during insulin therapy in the intensive care unit. Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE, 3297-3300 doi:10.1109/IEMBS.2008.4649909.
Celi L, Hinske L, Alterovitz G, Szolovits P An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study Critical Care, 2008 12:R151
Aboukhalil A, Nielsen L, Saeed M, Mark RG, Clifford GD. Reducing False Alarm Rates for Critical Arrhythmias using the Arterial Blood Pressure Waveform Journal of Biomedical Informatics Special Issue on Computerized Decision Support for Critical and Emergency Care, Volume 41, Issue 3, June 2008, pp 442-451, doi:10.1016/j.jbi.2008.03.003 Available online March 21st 2008.
Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for acute respiratory distress syndrome in patients mechanically ventilated for greater than 48 hours. CHEST 2008 133: 853-861.
Li Q, Mark RG, Clifford GD. Robust heart rate estimation from multiple asynchronous noisy sources using signal quality indices and a Kalman Filter. IOP Physiol Meas Jan 2008; 29(1):15-32. [Awarded the Martin Black Prize for Best paper in Physiological Measurement in 2008]
Neamatullah I, Douglass M, Lehman LH, Reisner A, Villarroel M, Long WJ, Szolovits P, Moody GB, Mark RG, Clifford GD. Automated De-Identification of Free-Text Medical Records. BMC Medical Inform Decis Mak July 2008;8:32 .
Uzuner Ö, Sibanda TC, Luo Y, Szolovits P. A de-identifier for medical discharge summaries. Artif Intell Med 2008; 42(1):13-35.ISSN 0933-3657.
Wolfberg AJ, DeRosier DJ, Roberts T, Syed Z, Clifford GD, Acker D, du Plessis AJ. A comparison of subjective and mathematical estimations of fetal heart rate variability. Journal of Maternal Fetal and Neonatal Medicine 2008; 21(2):101-4.
Zhang Y, Szolovits P.Patient-specific learning in real time for adaptive monitoring in critical care. J Biomed Inform June 2008; 41(3):452-60.

2007

Lian J, Clifford GD, Müessig D, Lang V. Open source model for generating RR intervals in atrial fibrillation and beyond. BioMedical Engineering OnLine March 2007; 6(9):1-16. Doi:10.1186/1475-925X-6-9.
Sameni R, Clifford GD, Shamsollahi MB, Jutten C. Multi-channel ECG and noise modeling: application to maternal and fetal ECG signals. EURASIP Journal on Advances in Signal Processing 2007; 2007(43407):1-14.
Sameni R, Shamsollahi MB, Jutten C, Clifford GD. A nonlinear Bayesian filtering framework for ECG denoising. IEEE Trans Biomed Eng December 2007; 54(12):2172-2185.
Uzuner Ö, Luo Y, Szolovits P. Evaluating the state-of-the-art in automatic de-identification. J Am Med Inform Assoc Sept/Oct 2007; 14(5):550-563.

2006

Clifford GD. A novel framework for signal representation and source separation. Journal of Biological Systems June 2006; 14(2):169-183.
He T, Clifford GD, Tarassenko L. Application of ICA in removing artefacts from the ECG. Neural Comput and Applic 2006; 15(2):105-116.
Heldt T. Continuous blood pressure-derived cardiac output monitoring - should we be thinking long term?. J Appl Physiol 2006; 101(2):373-374. Invited editorial.
Parlikar T, Heldt T, Verghese G. Cycle-averaged models of cardiovascular dynamics. IEEE Transactions on Circuits and Systems I Fundamental Theory and Applications 2006; 53(11):2459-2468.

2005

Clifford GD, Shoeb A, McSharry PE, Janz BA.Model-based Filtering, Compression and Classification of the ECG. International Journal of Bioelectromagnetism 2005; 7(1):158-161.
Clifford GD, Tarassenko L. Quantifying errors in spectral estimates of HRV due to beat replacement and resampling. IEEE Transactions in Biomedical Engineering 2005; 52(4):630-638.
Heldt T, Chang JL, Chen JJS, Verghese GC, Mark RG. Cycle-averaged dynamics of a periodically driven, closed loop circulation model. Control Engineering Practice 2005; 13:1163-1171.
Mukkamala R, Reisner TA, Hojman H, Mark RG, Cohen RJ. Continuous cardiac output monitoring by peripheral blood pressure waveform analysis. IEEE Transactions on Biomedical Engineering 2005; 53(3):459-467.

2004

Clifford G.D., Tarassenko L.: Segmenting cardiac-related data using sleep stages increases separation between normal subjects and apnoeic patients, IOP Physiol. Meas. 25 (2004) N27-N35. [Selected by the Institute of Physics for inclusion in IOP select. IOP select is a special collection of journal articles, chosen by IOP Editors based on one or more of the following criteria: 1) Substantial advances or significant breakthroughs, 2) A high degree of novelty or, 3) Significant impact on future research.]
Clifford GD, Tarassenko L. Segmenting cardiac-related data using sleep stages increases separation between normal subjects and apnoeic patients. IOP Physiol Meas 2004; (25):N27-N35.
Jager F, Moody GB, Mark RG. Protocol to assess robustness of ST analysers: a case study. Physiological Measurement 2004; 25(3):629-643.
Zong W, Moody GB, Mark RG. Reduction of false arterial blood pressure alarms using signal quality assessment and relationships between the electrocardiogram and arterial blood pressure. Med Biol Eng Comput 2004; 42:698-706.

2003

McSharry PE, Clifford GD, Tarassenko L and Smith L: A dynamical model for generating synthetic electrocardiogram signals. IEEE Trans Biomed Eng 2003; 50(3):289-294.

2002

Heldt T, Shim EB, Kamm RD, Mark RG. Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol 2002; 92(3):1239-1254.